Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the αPS1 integrin subunit
نویسندگان
چکیده
Danny L. Brower1,*,‡, Thomas A. Bunch1, Leona Mukai1, Todd E. Adamson1, Marcel Wehrli2,†, Suzanne Lam3, Eric Friedlander3, Carol E. Roote3, Susan Zusman3,* 1Department of Molecular and Cellular Biology, Life Sciences South Building, University of Arizona, Tucson, AZ 85721, USA 2MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK 3Department of Biology, University of Rochester, Rochester, NY 14627, USA
منابع مشابه
Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit.
We report on the generation and phenotype of mutant alleles of multiple edematous wings (mew), the gene encoding the alpha PS1 subunit of the PS1 integrin of Drosophila. None of the six alleles examined makes detectable protein, and one allele results from a chromosome break near the middle of the translated sequence, so we are confident that we have described the null phenotype. In contrast to...
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At the onset of pupariation in the Drosophila wing, the PS1 and PS2 integrins are expressed preferentially on the dorsal and ventral wing epithelia, respectively. Clonal analysis experiments have indicated that integrins are required to maintain the tight association of the wing surfaces. Surprisingly, we find that even in clones of cells lacking integrins the wing layers become apposed early i...
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تاریخ انتشار 1995